A buddy asked about this--enclomiphene citrate. Had never heard of it before. Did a search here and it is mentioned in another TRT thread.
Anyone else tried it or know anyone who's used it? Basically, did it work very well?
Here's a link to an interesting study--
www.ncbi.nlm.nih.gov
My insurance wouldn't cover enclomiphene w/o addtional headache AND no one in my region compounds it. I am currently on clomid 25mg/day and 25mg of exemestane EOD my total T is 807 and free is 417. I will be likely switching to either anastozole or letrozole for a better terminal half-life, therefore more stable long term blood plasma levels. For a quick cost comparison I think I'm paying about $30/month for my combo vs the $130 or so depending on the online vendor.
Several studies show that AI's reduce SHBG so I suspect that is why free/bio test is going up. I also came across one yesterday in a Letrozole study that had the following results:
Total testosterone rose from 5.9+/-0.5 to 19.6+/-1.4 nmol/l (P<0.001), and free testosterone from 163+/-13 to 604+/-50 pmol/l (P<0.001). Total testosterone rose to within the normal range in all subjects, whereas free testosterone rose to supraphysiological levels in 7 out of 12 men. The testosterone and E(2) levels were stable throughout the week and during the 6-month treatment period.
It appears that the potential for some to have a positive response that could mimic teenage/early 20's free/bio available potential is there. Admittedly, my research revolves around studies and their results on LH, FSH, SHBG and bio/free test. Total T doesn't mean squat if your SHBG is chewing up its bioavailibility.
I'd love to see someone here on injectable HRT/TRT add an AI for 2 months just to see what happens to free/bio T, before and after. In theory it should rise but I cannot find any studies yet that have been conducted as such and/or only abbrevated abstracts are available on pubmed/NCBI.